I have worked with 2 multi-media worship software(Easyworship and Propresenter)over the years and both are user friendly and easy to setup, well easyworship was the easiest especially for a small to medium church setup! However the bigger you go with multiple displays, live video, multiple layers, Propresenter is the way to go!  

At Grace performing Arts Centre  we are running Propresenter and PVP(Provideo player). Check out these 2 worship software packages in the links below and decide for yourself. Contact me if you need further help or info.